Money,banking and the federal reserve system Essay

Money,banking and the federal reserve system - Essay Example In order to ensure a balance of the bank reserves and to control the monetary base, the Federal Reserve was established. For efficient use of money in the United States, the Banks and the Federal Reserve work together. Money is the most widely used liquid asset in the world today. Cash is the liquid form of money that is applicable and usable in many of the small and medium business ventures. However, there are other forms of money acceptable in many places. These include traveler’s checks, and checkable bank deposits. Money has the capability of generating gains from trading activities since its nature allows indirect exchange. It also provides a uniform way of transacting given that every product or service can be exchanged with money. It contradicts the barter system of trade (Krugman 412). Money plays three main functions in the United States economy. Firstly, it the sole medium of exchange across the country, it is possible to obtain any goods and services in exchange of money. This medium of exchange lacks the capability to be consumed hence it has to be applied in obtaining consumable goods and pay fro services. Hard economic times have called for use of different monetary forms. This has been evident in some Latin American countries that have resulted into the use of the American dollar, a situation also seen in Eastern Europe where they have used Euros. Secondly, it is used as a store of value, meaning money has the ability to purchase power over a given period. Other assets complement money as a store of value but its uniqueness is that its value appreciates in most cases. Lastly, money is a unit of account. In accounting, money is widely accepted as the medium of setting prices and calculating the value of other assets 413-414. The concept of money has continued to change with time. In historical times, silver and gold were considered as the medium of exchange, this was facilitated by their valuable nature in making of making of ornaments and jewellery. Around independence time in 1776, paper money was getting used to complement the gold and the silver coins. The transition saw the introduction of commodity-backed money that whose value was dependent on the promise that it could be possible to turn it into value on demand. (Krugman 414).To further enhance the monetary form, the United States Dollar was adopted as a generally acceptable mode of transacting in exchange of goods and services. This introduced the so-called fiat money that derives its value from the official status it adopts. This type of money has advantages over the former types in that it does not use other resources apart from the material used in its making and secondly, its supply can be regulated to take care of specific economic needs. However, the challenge remains in production of fake currency (Krugman 415). There are two types of monetary aggregates, denoted by the Federal Reserve as M1 and M2. M1 entails the cash, traveller’s checks and ch eckable bank deposits. Other near-moneys are inclusive in M2. In the United States, year 2011 September, M1 was equivalent to $2,136.9 billions while M2 was $9,603.6 billions of dollars (Krugman 416). Near-moneys are accompanied by interests that the cash dos not, this is the reason why they pay higher interests than checkable bank deposits. Banks plays a critical role in the money industry in the United States and all over the world. It is evident that banks play a role in linking the Federal Reser

The Gothic Mode as Subversive Essay Example for Free

The Gothic Mode as Subversive Essay Why is Gothic literature considered subversive? First we consider the definition of subversive. Anything that works against the dominant culture is called subversive. Gothic literature focuses on death and decay, which is a negative attitude. The majority of Gothic writers are not motivated by any high ideals. Instead they are intent on making money, and so aim for cheap thrills. A good example is the â€Å"penny-dreadfuls† of the Victorian era, which were cheap serializations of bloodthirsty tales carrying titles like ‘Varney the Vampire’. The Gothic mode is not necessarily subversive. If it can be shown that the Gothic mode is expressive of culture, and therefore does not work against it, we may conclude that it is not necessarily subversive. It may be argued that Gothic is a subgenre of Romanticism, which is acknowledged to be a cultural phenomenon. There are possible exceptions, and authors may always take advantage of a popular medium, and will strive to pander to basic instincts. But the strategy is to show that there is an underlying social need that Gothic literature addresses to, and therefore it cannot be called antisocial. What it Romantic literature, and how do the Romanticists evaluate Gothic? Romantic literature is professed to be that which emphasizes imagination over reason. William Wordsworth is a leading light of Romanticism, and the Preface which he wrote for the second edition of his Lyrical Ballads is seen by many to be the manifesto of the movement. In the same Preface Wordsworth reacted violently against the Gothic genre, averring that â€Å"the human mind is capable of excitement without the application of gross and violent stimulants; and he must have a very faint perception of its beauty and dignity who does not further know that one being is elevated above another in proportion as he possesses this capability† (2004, p. 6). Wordsworth conceives Romanticism as an philosophical ideal. According to this ideal Romantic literature is meant to ennoble human passion and feeling. Gothic literature does not seem to measure up to this ideal, and so it is rejected by the Romanticists. Why the Romanticists are wrong in their assessment of Gothic literature, in the context of Horace Walpole’s The Castle of Otranto? The Romanticists fail to acknowledge that their philosophy is rational, and therefore they are advocating a merger of reason and imagination, and they are not merely surrendering themselves to imagination alone. Analysing the substance of Horace Walpole’s The Castle of Otranto, we also find a marriage between the imaginary and the factual. The novel is of imaginative content, and yet it is eager to establish itself as factual. To this end Walpole interposes himself as mere translator of an ancient manuscript that has newly been discovered. The long title and the extended Preface go to great lengths to establish this pretence. The substantive part of the novel is also engaged merely in keeping up this pretence, and therefore to keep the original mood intact. There is a succession of mysterious occurrences, laced with energizing diction, which creates an aura of continuous suspense and action, without any effort towards a coherent and unified story. The setting of the story is all important, and it is meant to be evocative of a mysterious past. The pretence towards factuality is merely meant to be a trigger to the imagination. Thus, the factual leads to the imaginative, and the imaginative to the factual. In this way the two aspects are merged. This is why Walpole’s novel should be classed as Romantic. Gothic literature as protest. Romanticism was a protest against the ethos of the Enlightenment. The latter was a 18th century phenomenon that emphasized reason above all else, and looked back to ancient Greece and Rome for inspiration. The Romanticists felt that too much stress on reason suppresses the imagination. If Gothic be classed as Romanticism we should be able to identify in it the same protest. Indeed, the earlier manifestation of Gothic in the context of architecture was indeed a protest of the same sort. The â€Å"Gothic revival† was a phenomenon that originating in Germany, and was a protest against the humanist tendencies of the Italian renaissance. It meant to re-establish the medieval values of religion and community against the atheist and cosmopolitan tendencies of Italy. It was mainly expressed through the architecture of churches, abbeys and cathedrals. Its ornateness was deliberately pitched against the homogenizing tendency in classical art. Its elongated spires and arches were deliberately pointed towards heaven, emphasizing the otherworldly, which was a protest against the humanist ethos which wants to flatten all things to the earth. Gothic architecture is indeed a precursor to the Romanticism of the 18th century, which was also a reaction against neoclassicism and the humanist ethos. Margaret Drabble suggests that the ‘Gothic’ in the title merely means medieval, so that â€Å"Gothic tale† merely means â€Å"medieval tale† (1995, p. 412). This may be true, but the term carries far more significance. It originally referred to the architectural style, which originates from Germany, the land of the Goths. The eponymous Castle of Otranto is a Gothic building. Following Walpole’s cue the genre itself came to be heavily dependent on such ‘Gothic’ settings. It may be argued that Gothic literature is not only characterized by setting. Indeed, we may detect in it the same philosophy which has animated the Gothic revivalism of Germany. In this way Gothic literature is a protest, and coincides with the protest of Romanticism. This will establish the Gothic mode of literature to be a subgenre of Romanticism, and therefore no longer subversive. Why the fascination with death? The Marquis de Sade offers a contemporary explanation of the Gothic fascination with death. In his Ideas on the Novel suggests that it was the shock of the French Revolution that caused literature to react in such an unusual way. He continues, â€Å"For one who knew all the miseries with which the wicked can afflict humanity the novel became as difficult to create as it was monotonous to read† (qtd. in Bruhm 1994, p. 161). In short, a new form of literature was required to take the place of the defunct optimistic strain of the Enlightenment. The chaos and terror unleashed by the Revolution represents a terrible shock to the general ethos of the age, and something that defied comprehension. The reflection of this in literature was the advent of the Gothic mode. The unsettled imagination refocused on death, instead of on light and life, as was characteristic of the Enlightenment. But against this it may be argued that in previous ages people has turned to the supernatural for comfort in periods of discontent. The supernatural is not a part of the the Gothic, which is more inclined towards the natural and the factual. It may also be argued against Sade that Gothic literature begins well before the storming of the Bastille. In this light, it is more reasonable to see the genre as an extension of Romanticism, and as constituting part of the same Romantic protest. From this point of view the French Revolution itself is a confirmation of the fears inherent in the Romantic protest. Gothic as a corrective to the ethos of the Enlightenment. Gothic should be properly seen as a protest against the cold calculation of extreme rationalism. The Enlightenment focused on light and life, and therefore tended to overlook death. It believed that with the light of reason all obstacles could be overcome. But the French Revolution functioned as a staggering reminder of death. Even before the revolution the subconscious sought to explain death, which clarifies the Gothic fascination. Karl Marx warns us that â€Å"the tradition of all the generations of the dead weighs like a nightmare on the brain of the living† (1963, p. 1). To ignore death is a form of suppression. Therefore, Gothic taste for death is best explained as a corrective to the ethos of the Enlightenment. In the age of reason men were reluctant to turn to the supernatural. Instead the focus was on death in outlandish and displaced circumstances. Analysing the issue David Punter comes to the conclusion that â€Å"[w]ithin the Gothic we can find a very intense, if displaced, engagement with political and social problems† (1994, p. 56). The engagement, as we have seen, is through a focus of death, and the displacement takes place through setting the narrative in the medieval period, or in ‘Gothic’ setting which is evocative of a bygone age. How Gothic relates to Romanticism proper, and the question of being subversive revisited. The proper strain of Romanticism claims to work against the rationalist ethos. But it too fails to consider death, and prefers to dwell on the ‘higher’ ideals of feeling and imagination. The Gothic mode makes up for this lack in Romanticism, and therefore must be considered more Romantic, than a typical work of Blake or Wordsworth, for it is spontaneous in its composition, and is not burdened by a conscious philosophy. Gothic literature can be said to have sprung from the context of its age. It professes all the Romanticism does, but in an entirely natural way. If Romanticism is a protest against the strictures of rationalism and neoclassicism, then Gothic literature is too. In this context it is significant to note that the Gothic mode is still vigorously active to this day, while Romanticism is now studied as a historical phenomenon. This is testimony of the authenticity of the Gothic, as against the measured cadences penned by Wordsworth. The essential value of Gothic literature is attested to from many respectable quarters. Commenting on the genre, Edgar Allan Poe says that â€Å"terror is not of Germany, but of the soul† (qtd. in Asselineau 1970, p. 17). Assessing the works of Ann Radcliffe, arguably the greatest of the early Gothic writers, Donald Spector says that â€Å"she united terror and beauty† (1963, p. 6). These comments are indicative of the profundity and beauty contained in works that are otherwise merely sensationalist and lightweight on the surface. In Northanger Abbey Jane Austen provides a spoof of the genre which is at the same time an affirmation. The naive heroine, Catherine, who is addicted to Gothic fiction, and lives in her imagination, in thrown headlong into the world to learn the ropes. Henry Tilney is attracted to her because of her naivete, and enthuses about her literary taste: â€Å"The person, be it gentleman or lady, who has not pleasure in a good novel, must be intolerably stupid† (Austen 2003, p. 77). Austen portrays Henry as a paragon of common sense, and so it is not unlikely that his opinion is that of the author. Catherine has an irresistible urge to believe in Gothic literature, so when she comes upon a real Gothic abbey she begins to imagine dark designs in every unusual detail. Austen demonstrates that even in parody the gothic mode is intrinsically exciting, and to deny such pleasure is a mark of literary snobbishness. She intends to explain rather than condemn. The continuing relevance of the Gothic mode. The inference is that the Gothic genre tries to make sense of death when the rational core of society is in denial. Rationalism is by nature retrospective, and Emerson explains, â€Å"Our age is retrospective. It builds the sepulchres of the fathers. It writes biographies, histories, and criticism. The foregoing generations beheld God and nature face to face; we, through their eyes† (2003, p. 181). Out failure to apprehend nature directly leads to alienation, which Gothic literature means to address. In its original context the Gothic was a protest against the cold calculation of extreme rationalism, and the same argument may be provided to explain its continuing appeal in modern mechanized society. Rationalism argues selectively from the past, but carefully ignores death. This is a form of suppression. Gothic literature is deemed to be subversive because of a seemingly unhealthy appetite for death. But when seen in the context of overcoming suppression and alienation, we must conclude that it is a mistake to classify Gothic literature as necessarily subversive. References ASSELINEAU, R. , 1970. Edgar Allan Poe. Minneapolis: University of Minnesota Press. AUSTEN, J. , 2003. Northanger Abbey, Lady Susan, The Watsons, Sandition. Oxford: Oxford University Press. BRUHM, S. , 1994. Gothic Bodies: The Politics of Pain in Romantic Fiction. Philadelphia, PA: University of Pennsylvania Press. DRABBLE, M. , 1995. The Oxford Companion to English Literature. Oxford: Oxford University Press. EMERSON, R. W. , 2003. Selected Writings of Ralph Waldo Emerson. Eds. W. H. Gilman, C. Johnson. New York: Signet Classic. MARX, K. , 1963. The Eighteenth Brumaire of Louis Bonaparte, With Explanatory Notes. New York: International Publishers. PUNTER, D. , 1996. The Literature of Terror: A History of Gothic Fictions. Upper Saddle River, NJ: Longman. SPECTOR, D. , (Ed. ) 1963. Seven Masterpieces of Gothic Horror. New York: Bantam. WALPOLE, H. ; BECKFORD, W. ; SHELLEY, M. W. , 1968. Three Gothic Novels: The Castle of Otranto; Vathek; Frankenstein. Eds. P. Fairclough, Mario Praz. New York: Penguin Classics. WORDSWORTH, W. , 2004. Lyrical Ballads with Other Poems 1800. Whitefish, MT: Kessinger Publishing.

Plant Medicines in Cancer Treatment

Plant Medicines in Cancer Treatment Review of Literature Plants as therapeutic agents Plant medicines are the most widely used medicines in the world today. The use of herbs and plants as the first medicine is a universal phenomenon. Every culture on earth, through written or oral tradition, has relied on the vast variety of natural chemistry found in healing plants for their therapeutic properties (Serrentino 1991). Plants with therapeutic potential may be defined as any plant that can be put to culinary or medicinal use. Recent researches found that food and their constituents act in a manner similar to modern drugs without the dreaded side effects (Serrentino 1991). Sometimes plant medicine is viewed as complementary medicine, working closely with allopathic drugs. Nearly 5.1 billion people worldwide employ natural plant-based remedies as their primary medicines for both acute and chronic health problems, from treating common cold to controlling blood pressure and cholesterol (Stockwell, 1988). Most of the drugs were substances with a particular therapeutic action extracted from plants. Some medicines, such as the cancer drug Taxol from Taxus brevifolia and the anti-malarial quinine from Cinchona pubescens are manufactured from the plants. Other medicinal agents such as pseudoephedrine originally derived from ephedra species and methylsalicylate, derived from gaultheria procumbens are now synthesized. Plant medicines remain indispensable to modern pharmacology and clinical practice. Much of the current drug discovery and development process are plant-based, and new medicines derived from plants are inevitable. Functional foods A food can be regarded as a functional food if it is demonstrated to affect one or more target functions in the body beyond adequate nutrition and improves health/well-being or reduces the risk of diseases (Tsao and Akhtar, 2005). On this basis, a functional food can be a natural food, a food to which a positive component has been added, or from which a deleterious component has been removed or a food where the nature of one or more components has been modified (Tsao and Akhtar, 2005). While searching for new sources of functional food, attention has been paid to vegetables from the Cruciferae family, which more often used in the human diets. The cruciferous vegetables may thus become a potential source of a nutritious food or food ingredients. Recent research showed that cruciferous vegetables contain an appropriate amount of bioactive compounds such as GLs, ITCs, tocopherols, L-ascorbic acid, vitamin B, reduced glutathione, inositol phosphates and polyphenolic compounds [Nakamura e t al, 2001; Zielinski and Kozlowska, 2003; Zielinski et al, 2005; Takaya et al, 2003]. Cruciferous plants The family Cruciferae (Brassicaceae) is an economically important family with about 350 genera and 3000 species that includes several edible plants. Despite the great diversity among the crucifers, members of only a few genera are eaten. The most commonly eaten cruciferous vegetables belong to the genus Brassica that includes broccoli, cabbage, cauliflower, kale and Brussels sprouts. Other cruciferous vegetables used in the human diet such as radish, water cress, wasabi, horseradish, garden cress, Italian cress, Swiss chard and crambe belong to another genera of the family such as Raphanus, Nasturtium, Wasabia, Armoracia, Lepidium, Eruca, Beta and Crambe respectively. Cruciferous vegetables are important dietary constituents in many parts of the world and appear to account for about 10 15% of total vegetable intake, reaching almost 25% in countries with a high consumption (Bosetti et al, 2002; Chiu et al, 2003). However, regional pattern of crucifer consumption varies substantially in different parts of the world. The highest intake of cruciferous vegetable was reported to that of people in China, who consumed more than 100 g per day, representing about one-fourth of their total vegetable intake (Chiu et al, 2003). Other Asians and some Middle Eastern populations in Japan, Singapore, Thailand and Kuwait also have a relatively high intake of cruciferous vegetables, ranging from 40 80 g per day (Bosetti et al, 2002; Seow et al, 2002; Shannon et al, 2002; Memon et al, 2002). However, the only study carried out in India (Rajkumar et al, 2003) showed a lower daily intake of cruciferous plants, of about 17 g per day. In North America, the daily estima ted consumption was in the range of 16 40 g per day (Lin et al, 1998) and in South America, it was about 3 15 g per day (Atalah et al, 2001). The daily intake of cruciferous vegetables was reported to be about 5 30 g per day in Europe (Bosetti et al, 2002), 50 g per day in Australia (Nagle et al, 2003) and 15 g per day in South Africa (Steyn et al, 2003) respectively. Raphanus sativus R. sativus is believed to have originated in southern Asia and was cultivated in Egypt. The first cultivated R. sativus was black variety and later on white and red R. sativus were developed. It was highly esteemed in ancient Greece, and the Greek physician Androcydes ordered his patients to eat R. sativus as a preservative against intoxication. The Japanese white R. sativus, also named daikon, is the vegetable for which the literature reports the highest per capita consumption, quoted at 55 g per day in Japan (Talalay and Fahey, 2001). In addition to this, Japanese also consumes R. sativus sprouts under the name of Kaiware Daikon. Varieties of R. sativus There are six main varieties of R. sativus such as Daikons, Red Globe, White Globe, Black, White Icicles and California Mammoth White Daikons (R. sativus L) This variety is native to Asia. They are large and carrot-shaped, have a white flesh that is juicy and a bit hotter than a red radish, but milder than black. Red Globe (R. sativus var. red) This variety is the most popular in the United States. It is small, round or oval shaped, referred to as button red radishes and have a solid crisp flesh. White Globe (R. sativus var.white) This variety is small and oval shaped, referred to as hailstone or white button. They have white flesh and milder than the red variety. Black (R. sativus var. niger) This variety is thought to be native to Egypt and Asia. They are turnip-like in size and shape. They are quite pungent and drier than other varieties of radishes. White Icicles (R. sativus L var. thin) This variety is long and tapered. They have a white flesh that is milder than the red variety. California Mammoth White (R. sativus L var. large) A larger variety than the white icicle, these varieties have oblong- shaped roots and their flesh is slightly pungent. Nutritive value of R. sativus R. sativus root and its leafy part are ideal vegetables as they provide an excellent source of vitamin C. Leafy part contains almost six times the vitamin C content of its root and also a good source of calcium and iron. R. sativus is also a good source of potassium and folic acid. It is very low in fats. Approximately, 100 g of raw vegetable provides roughly 20 Kcal, coming largely from carbohydrates (Table 2.1). Thus R. sativus is a dietary food that is relatively filling for its caloric value. Some sources list R. sativus as being rich in dietary fiber, whereas other sources differ in respect of its roughage content (USDA Nutrient Database, 1999; Duke and Ayensu, 1985). Health benefits of R. sativus (Traditional usage of R. sativus) According to Hakeem Hashmi, an eminent Unani physician from India, R. sativus is unparallel in curing any kind of ailments. All the parts of R. sativus including its seed, stem, root and leaves are used in food and medicine. R. sativus is a unique vegetable having a hot and cold effect on the body simultaneously. R. sativus, like other members of the cruciferous family (cabbage, kale, broccoli, Brussels sprouts) contains cancer-protective properties. Liver and gall bladder disorders Throughout the history, R. sativus root and seeds have been effective when used as medicinal food for liver disorders. They contain sulfur-based compounds such as GLs and ITCs that increase the flow of bile and help to maintain healthy gallbladder and liver (Chevallier, 1996). They are useful in treating jaundice and also an excellent remedy for gall bladder stone. Kidney disorders R. sativus root, seeds and leaves are diuretic in nature and increase the urine output. Their diuretic properties help to flush out the toxins accumulated in the kidneys and protect them from infections and inflammatory conditions. It is an old belief that R. sativus can aid in the treatment as well as prevention of kidney stones (Chopra et al, 1986). Respiratory disorders R. sativus is an anti-congestive and relieves congestion of the respiratory system. It has found to be beneficial in problems associated with bronchitis (Bown, 1995) and asthma (Duke and Ayensu, 1985). Skin disorders R. sativus helps to cure skin disorders such as leucoderma, rashes, cracks, etc and also refreshes the skin by maintaining the moisture content of the skin (Duke and Ayensu, 1985). Digestive disorders R. sativus root, seeds and leaves are rich in roughage (indigestible carbohydrates) which facilitates digestion, retain water and relieve constipation (Chopra et al, 1986). They also soothe the digestive system and stimulate appetite (Chevallier, 1996) Nervous and vascular disorders R. sativus decreases nervous tensions and is also useful in enhancing blood circulation. It is a remedy for insomnia, hypochondria and irritative conditions of the central nervous system (Panda, 1999). Other benefits R. sativus is germicidal and suppresses phlegm. It is a good appetizer, mouth fresher, laxative, regulates metabolism, remedy for headache, acidity, piles, nausea, obesity, sore throat, whooping cough, dyspepsia, etc (Nadkarni, 1976; Kapoor, 1990). Chemical constituents of R. sativus GLs are an important and unique class of secondary plant metabolites found in the seeds, roots and leaves of R. sativus (Daxenbichler et al, 1991; Blazevic and Mastelic, 2009). GLSs include several naturally occurring thioglucosides with a common structure (Figure 2.2) characterized by side chains (R) with varying aliphatic, aromatic and heteroaromatic carbon skeletons, all presumably derived from amino acids by a chain-lengthening process and hydroxylation or oxidation (Larsen, 1981). In the intact cell, GLs are separated from thioglucosidase (EC 3.2.3.11), an enzyme generally known as myrosinase. When the plant cell structure is damaged, myrosinase catalyzes the hydrolysis of GLs to yield D-glucose, sulfate and a series of compounds including isothiocyanates, thiocyanates and nitriles, depending on both the substrate and the reaction conditions, especially the pH (Figure 2.2). GLs are also hydrolyzed by thioglucosidase activity of the intestinal microflora (Jeffery and Jarrell, 2001). 4-(methylthio)-3-butenyl glucosinolate (glucoraphasatin), 4-(methylsulfinyl) butyl glucosinolate (glucoraphanin) and 4- (methylsulfinyl)-3-butenyl glucosinolate (glucoraphenin) are the most predominant GLs in the root and seeds of R. sativus (Daxenbichler et al, 1991; Carlson et al, 1985). These GLs on hydrolysis by myrosinase yield MTBITC, sulforaphane and sulforaphene respectively. GLs are not uniformly distributed and are highest in the distal end of the root, decreasing in upper root sections with the lowest level in vegetative tops (Esaki and Onozaki, 1980). Apart from GLs and their breakdown products, R. sativus also contains polyphenolics such as phenolic acid, flavonoids and anthocyanins. Several polyphenolic compounds including sinapic acid esters and kaempferol were isolated from R. sativus sprouts (Takaya et al, 2003). Twelve acylated anthocyanins (pelargonidin) were isolated from R. sativus red variety (Otsuki et al, 2002). Phytochemical screening showed the presence of other phytochemicals such as triterpenes, alkaloids, saponins and coumarins in R. sativus seeds (Mohamed et al, 2008). The myrosinase catalyzed hydrolysis of glucosinolates. (Adapted from Rusk et al, 2000) Novel classes of plant defensins (small basic cysteine rich peptides) such as Raphanus sativus antifungal peptide 1 and 2 (RsAFP1 and RsAFP2) were isolated from the seeds of R. sativus (Terras et al, 1992a). RsAFP1 and RsAFP2 are highly basic oligomeric proteins composed of small (5 KDa) polypeptides that are rich in cysteine. Both RsAFP1 and RsAFP2 have a broad spectrum antifungal activity and show a high degree of specificity to filamentous fungi (Terras et al, 1992b). They are active against both phytopathogenic fungi such as Fusarium culmorum and Botrytis cinerea (Terras et al, 1992b), human pathogenic fungi such as Candida albicans (Aerts et al, 2007) and occasionally possess antibacterial activity. However, they are non-toxic to humans and plant cells. R. sativus 2S storage albumins were identified as second novel class of antifungal protein (Terras et al, 1992a). They also inhibit the growth of different plant pathogenic fungi and certain bacteria (Terras et al, 1992a). At least eight distinguishable isoperoxidases were isolated and purified to apparent homogeneity from Korean R sativus roots. Among them are two cationic isoperoxidases such as C1 and C3 and four anionic isoperoxidases such as A1, A2, A3n and A3 (Lee and Kim, 1994). Plant peroxidases play an important role in several physiological functions such as removal of peroxide, oxidation of indole-3-acetic acid and toxic reductants, wound healing and cell wall biosynthesis (Hammerschmidt et al, 1982). Further, peroxidase represents an important component of an early response in plants to pathogen attack and plays a key role in the biosynthesis of lignin, which limits the extent of pathogen spread (Bruce and West, 1989). The products of this enzyme in the presence of a hydrogen donor and hydrogen peroxide have antimicrobial activity and even antiviral activity (Van Loon and Callow, 1983). Recently, a novel heme peroxidase intrinsically resistant to H2O2 was isolated from R. sativus (Japanese d aikon), which showed relatively stronger oxidative stability than that of reference horse radish peroxidase (HRPA2) (Rodrà ­guez et al, 2008). Biological activities of R. sativus Evidence from numerous investigations reveals that the biological and pharmacological functions of R. sativus are mainly due to its GLs and its breakdown products ITCs (Esaki and Onozaki, 1982; Nakamura et al 2001; Barillari et al, 2006; Papi et al, 2008). These compounds provide to R. sativus its characteristic odor and flavor as well as most of their biological properties. GLs and/or ITCs have long been known for their fungicidal, bacteriocidal, nematocidal and allelopathic properties (Brown et al, 1991) and have attracted intense research interest because of their cancer chemoprotective attributes (Fahey et al, 2001; Verhoeven et al, 1997). Polyphenolics, alkaloids, saponins, isoperoxidases and antifungal peptides are also accountable for significant part of the health benefits of R. sativus. These constituents are reported to exhibit several biological effects, including radical scavenging activity (Takaya et al, 2003), gut stimulatory, uterotonic and spasmogenic effects (Gilani and Ghayur, 2004; Ghayur and Gilani, 2005), anti-hyperlipidemic activity (Wang et al, 2002) and anti-atherogenic effects (Suh et al, 2006) and would perhaps work synergistically with GLSs and ITCs of R. sativus. Antioxidant activity Damage to proteins, lipids and DNA by reactive oxygen species (ROS) and reactive nitrogen species (RNS) can lead to a variety of chronic diseases such as cancer, cardiovascular, inflammatory and age-related neurodegenerative diseases (Borek, 1997; Richardson, 1993). ROS/RNS can damage cell membranes, disrupt enzymes, reduce immunity (Ahsan et al, 2003) and induce mutations (Loft and Poulsen, 1996). ROS/RNS are by-products of normal aerobic metabolism and could occur during mitochondrial/microsomal electron transport chain, phagocytic activity or generated from oxidase enzymes and transition metal ions (Nohl et al, 2003; Aruoma et al, 1989). Other sources of ROS/RNS are environmental factors such as pollution, sun damage, cigarette smoke or even some kinds of the foods (Schroder and Krutmann, 2004). These reactive species and the resulting oxidative damages are usually counteracted by the antioxidant defense mechanisms (Bagchi and Puri, 1998). Recent studies evidence that plant-based diets, particularly those rich in vegetables and fruits, provide a considerable amount of antioxidant phytochemicals such as vitamins C and E, glutathione, polyphenolics, sulfur containing compounds and pigments, which offer protection against cellular damage (Dimitrios, 2006). Vitamins Ascorbic acid is found to be the most effective antioxidant in inhibiting lipid peroxidation initiated by a peroxyl radical initiator among several types of antioxidants including a-tocopherol (Fei et al, 1989). Ascorbic acid is also capable of scavenging hydrogen peroxide, singlet oxygen, superoxide and hydroxyl radicals efficiently (Fei et al, 1989). It is also involved in the regeneration and recycling of tocopherols and ß-carotene (Niki et al, 1995). Numerous studies have shown that ascorbic acid is effective in lowering the risk of developing cancers (Block, 1991) and cardiovascular diseases (Trout, 1991). In spite of the overwhelming evidence on the health benefits, however, there are reports that demonstrated the pro-oxidant activity of ascorbic acid (Podmore, 1998). Tocopherols are essential vitamins with their major role as antioxidants in protecting polyunsaturated fatty acids (PUFAs) and other components of cell membranes and low-density lipoprotein (LDL) from oxidation , thereby preventing the onset of heart diseases (Rimm et al, 1993). Polyphenolics Polyphenolics is an extremely comprehensive phrase that covers many different subgroups of phenols and phenolic acids. These compounds are most commonly present in fruits and vegetables. They are essential to the physiology of plants, being involved in diverse functions such as lignification, pigmentation, pollination, allelopathy, pathogen/predator resistance and growth (Haslam, 1996). Polyphenolics include single-ring structure such as hydroxybenzoic acids and hydroxycinnamic acids and multi-ring structure such as flavonoids, which can be further classified into anthocyanins, flavan-3-ols, flavones, flavanones and flavonols. Some of the flavonoids such as flavan-3-ols can be found in their dimeric, trimeric and polymeric forms. Most of the polyphenolics are often associated or conjugated with sugar moieties that further complicate the polyphenolic profile of vegetables. Polyphenolics are especially important as antioxidants, because they have high redox potentials, which permit the m to act as reducing agents, hydrogen donors, singlet oxygen quenchers and metal chelator (Kahkonen et al, 1999) and alleviate free radical mediated cellular injury (Shahidi and Wanasundara, 1992). The antioxidant ability of individual polyphenolics may differ, but, as a group, they are one of the strongest groups of antioxidants. The antioxidant activity of a polyphenolic compound is chiefly determined by its structure, in particular the electron delocalization over an aromatic nucleus (Tsao and Akhtar, 2005). When these compounds react with a free radical, delocalization of the gained electron over the phenolic antioxidant and the stabilization of the aromatic nucleus by the resonance effect take place that prevent the continuation of the free radical-mediated chain reaction (Tsao and Akhtar, 2005). Sulfur-containing compounds GLs are a group of sulfur-containing compounds found in the cruciferous plants such as R. sativus, broccoli, cabbage, mustard, wasabi etc. These compounds are found to be strong antioxidants, which are indeed through activation of detoxification enzyme mechanisms for the efficient removal of xenobiotics, rather than through direct radical scavenging capability (Zhang and Talalay, 1998). This property of GLs and its hydrolysis products ITCs is considered as one of the major contributors to its anti-cancer activity (Zhang and Talalay, 1998). Antioxidant activity of R. sativus R. sativus is one of the major sources of dietary phenolic acids and flavonoids, which are mostly present as sugar conjugates (Takaya et al, 2003). The major phenolic acids found in R. sativus sprout are sinapic acid and ferulic acid, which are present in conjugated form as 1-sinapoyl-1-ß-D-glucopyranoside, ß-D-(3-sinapoyl) frucofuranosyl -a-D-(6-sinapoyl) glucopyranoside and 1-feruloyl-ß-D-glucopyranoside (Takaya et al, 2003). The major flavonoids present in R. sativus sprouts is kaempferol that occurs in a conjugated form as kaempferol-3,7-O- a-L-dirhamnopyranoside and kaempferol-3-O- a-L-rhamnopyranosyl-(1-4)- ß-D-glucopyranoside (Takaya et al, 2003). Lugasi et al (1998) demonstrated the strong antioxidant property of squeezed juice extracted from a black R. sativus root through its ability to donate electrons, chelate metal ions and scavenge free radicals in a H2O2/ ·OH-luminol system. Since HPLC analysis revealed the presence of a considerable amount of GLs degradation products and polyphenols in the squeezed juice of black R. sativus, antioxidant activity of black R. sativus root could be attributed to these compounds. Takaya et al (2003) tested methanolic extracts from 11 different plants including Daikon R. sativus sprouts for their ability to scavenge free radicals. Daikon R. sativus sprouts proved to be the most potent, almost 1.8 times more effective than Vitamin C. Souri et al (2004) studied the antioxidant activity of 26 commonly used vegetables in Iranian diet and found that methanolic extract of R. sativus leaf significantly inhibited the peroxidation of linoleic acid as compared to standard antioxidant such as a-tocopherol and quercetin. Katsuzaki et al (2004) found that hot water extract of Daikon R. sativus extract showed more significant antioxidant activity than the extract obtained at an ambient temperature. L-tryptophan was isolated and identified as the compound responsible for the antioxidant activity. They also found that L-tryptophan changed to 5-hydroxy tryptophan (5-HTP), a precursor to serotonin in the rat liver microsome model system. A plant-based 5-HTP supplement is popular for its anti-depressant, appetite suppressant and sleep aiding properties. Lugasi et al (2005) further demonstrated that squeezed juice from black R. sativus significantly alleviated the free radical reaction in rats with hyperlipidaemia by decreasing the lipid peroxidation reactions and by improving the antioxidant status. Recent study also showed that R. sativus extract reduced the extent of lipid peroxidation in a dose dependent manner in rat liver homogenate treated with cumene hydroperoxide by increasing the levels of reduced glutathione and thereby protecting the liver from the toxin induced oxidative damages (Chaturvedi, 2008). Salah-Abbes et al (2008a) showed the protective effect of Tunisian R. sativus root extract against toxicity induced by zearalenone in mice by virtue of its ability to alleviate oxidative stress through stimulation and improvement of the antioxidant status. Polyphenolics in R. sativus may act in a synergistic or additive manner with GLs and/or ITCs and exert their antioxidant activity through inhibition of lipid peroxidation, enhancing the cellular antioxidant enzymes and increasing the glutathione in the cells. Apart from these phytochemicals, R. sativus also contain several classes of peroxidases that could play a significant role in the elimination of toxic peroxides and thus reduce the impact of free radical mediated cellular injury (Wang et al, 2002). Antimicrobial activity Infectious diseases are the worlds leading cause of untimely death, killing approximately 50,000 people every year. Bacteria have a remarkable ability to develop resistance to most pharmaceutical antibiotics. An increase in such antibiotic-resistant bacteria are menacing the human population with a recurrence of infectious diseases that were once thought to be under control, at least in developed countries (Pinner et al, 1996). These antibiotic-resistant bacteria have also caused unique problems in treating infections in patients with cancer and AIDS (Dennesen et al, 1998). Since tenacious and virulent bacteria develop immunity to solitary antibiotics at an alarming speed, there is an imperative need for a holistic targeted approach to search for novel antimicrobials from natural sources, especially from plant kingdom. Long before mankind ascertained the existence of microbes, the fact that certain plants had therapeutic potential was very well accepted. Since ancient times, man has used plants as the widespread remedial tool to treat common infectious diseases. Some of these traditional medicines are still included as part of the habitual treatment of various maladies. Bearberry (Arctostaphylos uva-ursi) and cranberry juice (Vaccinium macrocarpon) are employed to treat urinary tract infections, while species such as lemon balm (Melissa officinalis), garlic (Allium sativum) and tee tree (Melaleuca alternifolia) are described as broad-spectrum antimicrobial agents (Heinrich et al, 2004). Plant based antimicrobials represent a vast unexploited source for medicines, which need to be explored further. They have an immense therapeutic potential as they are effectual in the treatment of infectious diseases while concomitantly alleviating many of the side effects that are frequently connected with synthetic antimicrobials (Cowan, 1999). Plant based anti-infective agents generally have manifold effects on the body and often act beyond the symptomatic treatment of the infectious diseases. Plants have a virtually unlimited capacity to produce secondary metabolites, especially for their defense against predation by microorganisms, insects and herbivores. Many of these secondary metabolites give plants their characteristic odors and also responsible for plant pigments. Antimicrobial phytochemicals are divided into several categories based on their structural similarity as follows: Phenolic acids These are the simplest bioactive phytochemicals consisting of a single substituted phenolic ring. Cinnamic acid and caffeic acids are the common representatives of this group. Phenolic acids are reported to be effective against viruses (Wild, 1994), bacteria (Brantner et al, 1996) and fungi (Duke, 1985). The number and site of the hydroxyl group on the phenol structure are considered to be related to their relative toxicity to microorganisms. Phenolic acids which are in the higher oxidized state are often more inhibitory towards microorganisms than the one with the lower oxidation state (Scalbert, 1991). Thus the mechanisms thought to be responsible for the antimicrobial activity of phenolic acid could include enzyme inhibition by the oxidized compound through interaction with SH groups or through nonspecific interaction with the microbial proteins (Mason and Wasserman, 1987). Quinones They are aromatic compounds with two ketone substitutions in the phenolic ring. They are ubiquitous in nature and show general antimicrobial properties (Duke, 1997). They are extremely active as they can switch between hydroquinone and quinone through oxidation/reduction reactions. Quinones bind with proteins irreversibly, leading to inactivation of proteins and loss of function (Stern et al, 1996). They may also make substrates unavailable to the microbes. Flavonoids They are phenolic structures containing hydroxyl groups. They are ubiquitous and are commonly found in fruits, vegetables, nuts, tea, wine, honey, etc. They are known to be effective antimicrobial compounds against a wide variety of microorganisms (Cushnie and Lamb, 2005). Catechins are the most extensively researched flavonoids for their possible antimicrobial activity due to their occurrence in green tea (Toda et al, 1989). Flavonoids have the ability to complex with extracellular proteins as well as with bacterial cell walls, rendering them inactive (Cushnie and Lamb, 2005). More lipophilic flavonoids may also have the ability to disrupt microbial membrane (Tsuchiya et al, 1996). Terpenoids and essential oils Essential oils are secondary metabolites that are highly supplemented in compounds based on an isoprene structure (Cowan, 1999). They are called as terpenes and usually occur as di, tri, tetra, hemi and sesquiterpenes. When the compounds contain extra elements such as oxygen, they are called as terpenoids. Camphor, farnesol, artemisin and capsaicin are the common examples of terpenoids. Terpenes and terpenoids are active against an array of bacteria (Habtemariam et al, 1993) and fungi (Rana et al, 1997). Previous research showed that terpenoids present in the essential oils of plants could be useful in the control of Listeria monocytogenes (Aureli et al, 1992). The mechanism action of terpenes is not yet established precisely, but is speculated to be due to the disruption of bacterial cell membrane by the lipophilic terpenoids (Mendoza et al, 1997). Alkaloids Alkaloids constitute large groups of compounds containing a nitrogen atom in a heterocyclic ring, with a broad range of biological activities. The first medically functional alkaloid was morphine isolated from Papaver somniferum (Fessenden and Fessenden, 1982). Alkaloids are generally found to have potent antimicrobial activity (Ghoshal et al, 1996). Solamargine, a glycoalkaloid from the berries of Solanum khasianum reported to be useful against HIV infection and intestinal infections associated with AIDS (McMahon et al, 1995). Berberine is an important and frequently studied member of the alkaloid group. It is potentially efficient against trypanosomes (Freiburghaus et al, 1996) and plasmodial infections (Wright et al, 1992). The mode of action responsible for the antimicrobial activity of alkaloids may be attributed to their ability to intercalate with DNA and arresting the metabolic activity of the bacterial cells (Phillipson and ONeill, 1987). Sulfur-containing compounds Sulfur-containing compounds encompass a wide array of compounds and usually found in the plants as glucosides (glucosinolates, alliin, etc). These glucosides, during the rupturing of the plant cell wall, are hydrolyzed into volatile sulfur compounds such as ITCs, allicin, allyl sulfide, diallyl disulfate, etc. Biological activity of sulfur-containing compounds is considered to be chiefly due to glucoside degradation products, as intact glucosides usually display much fewer biological activities than their subsequent hydrolysis products (Donkin et al, 1995). The mechanism of action responsible for the antimicrobial activity of sulfur-containing compounds varies. Antimicrobial activity of ITCs, degradation products of GLs, is thought to be related to its NCS group, in which the central carbon atom is highly electrophilic, which could interact irreversibly with

John Fowles Essay -- Biography Biographies Essays

John Fowles It's A Boy! Robert and Gladys Richards Fowles give birth to a baby boy on March 31, 1926, in Leigh-on-Sea, Essex County, England. The proud parents have high hopes for their son and send him to two prestigious schools, Alleyn Court School (1934-1939) and Bedford School (1939-1944), where he excels in scholarship and sports. After his primary education is complete, the family moves from London to the Devon countryside, to avoid the invasion of troops in World War II. After serving two years in the Royal Marines (I 945 -1947), John Robert Fowles studied literature at Oxford University, graduating in 1950. He greatly admired Albert Camus and Jean-Paul Sartre, both existentialist writers. After graduation Fowles taught at a number of institutions, including Anargyrios College (1951-1953) where he met and married his wife, Elizabeth Whitton. Here, he wrote poetry and several novels, though he did not submit any for publication at this time. Fowles continued to teach in London until his writing enabled him to concentrate on a career as a writer. His first published novel in 1963, The Collector, was an immediate best seller. The critical acclaim and commercial success of the novel finally allowed Fowles to write full time. A collection of art and philosophical thoughts called The Aristos appeared in 1964. His most enduring work, The Magus, has become something of a popular cult novel in the United States. It involves the traditional quest narrative with elaborate twists and dilemmas resembling a detective story. In the 1970's Fowles began a line of projects, from a series of essays to a collection of poetry called Poems. Besides writing his own poems, short stories, screenplays, and novels, Fowles has translated Fr... ... resembles Victorian society while also showing the reader the similarities to the present day. His attempts to demonstrate the double standards of all societies continue to be seen throughout his other works. The dualistic recurring theme penetrates the minds of the readers and keeps them coming back to Fowles' work. The French Lieutenant's Woman, because of its modem day comparisons and success with the public, is now a motion picture starring Meryl Streep in the title role. Fowles' accomplishments in writing continue to gain him critical acclaim and popularity with readers. He continues to write today with his latest work, Wormholes, published in May, 1998. Certainly, Fowles' success in his writing career has made his parents proud and confident of his success in the future. Work Cited Fowles, John. The French Lieutenant's Woman. Signet: New York, 1969.

Candide by Voltaire Essay

1) What is the relationship between Candide’s adventures and Pangloss’s teachings? In Candide, we see lives filled with struggles and tragedy. Although Candide witnessed and fell victim to worldly evils of cruelty and suffering, he maintained his optimistic views through much of the novel. Candide picked up this idea of optimism through Pangloss’s teachings. Although he did not see any good reasons to disbelieve Pangloss’s teachings while living in the Baron’s castle, once in the outside world, Candide experiences many tragic events that make him, and the reader, question the philosophy of optimism. Candide’s adventures, starting when he is kicked out of the Barons castle, clearly represented an imperfect world, full of atrocities that contradicted Pangloss’s teachings. The events that break apart Pangloss’s teachings begin almost immediately when Candide is thrown in the streets to live on his own. He runs into recruiting officers of the King of Bulgars. They have him toast to the health of their king, but then beat Candide severely and put irons on his legs. Luckily though, the king comes by and tells them to spare Candide since he is innocent. Soon after that, Candide witnesses an awful, bloody battle between two armies. This horrible spectacle shows us how hateful and violent people are in this world. Later, he finds a beggar who turns out to be Pangloss. Pangloss shares some of the horrible things he had been put through and that Candide’s one and only love had been raped and her entire family had been murdered when the Baron’s castle had been taken over. Once with Pangloss, he has many new adventures. While out at sea with Pangloss and Jacques, a violent storm occurred and destroyed their ship. Many innocent passengers are killed including Jacques, who died saving a sailor. The innocent passengers’ deaths disprove Pangloss’ theory since it appeared the bad that came out of the shipwreck led to nothing good for them; instead, only brought them to their deaths. When the sailor, Pangloss, and Candide get into Lisbon, an earthquake destroys most of the city. A  tidal wave also crushes ships in the port. In an effort to prevent another earthquake, wise men take ridiculous actions against the slightest wrongdoing. Candide and Pangloss end up getting arrested. Pangloss is hanged and Candide is beaten badly. The ridiculous actions taken place prove to be futile when another earthquake erupts the next day. All of the bad that came from the first earthquake provided no good. Pangloss had been hung for no reason and Jacques, a good man, had died from the storm out at sea. The reader is left wondering how these horrible events could result in a greater good. Candide finds that God might have spared one place on earth, El Dorado. He finds this seemingly perfect city, yet does not want to stay because is still in love with Cunegonde. The king gives him and Cacambo a few sheep and some gold. This portion of the story brings a little light, yet the whole world cannot be like El Dorado, and people who do live in perfect worlds cannot even appreciate it because they have nothing to compare the high points against. Since life is always perfect, they live in lethargic boredom and cannot truly appreciate how well off they truly are. We also see times of happiness and good fortune that restore Candide’s faith in optimism throughout the book. Such periods include when we find Pangloss survived, and the points in the book when Candide and Cunegonde get to be together, even for short amounts of time. Towards the end of the story, Candide begins to question Pangloss’ philosophy more and more. Although we find events that support optimism, we find more counterexamples. Although Pangloss and the Barons son are found alive, they tell Candide their escapes from death, and the tortures they had been put through afterwards. Soon after they free Pangloss and the Baron’s son from slavery, the men go and find Cunegonde, the woman Candide had been searching to live with and love for his entire life. When they do find her, she is extremely ugly and Candide no longer wants to marry her. Although he is no longer attracted to her, he is a man of his word and feels he must do his duty to take care of her and love her. Now, he is stuck with a woman he no longer lusts over. Candide has finally found what he had been sacrificing for all of his life to find, yet is not satisfied with what he has acquired  for his hard work. Throughout the entire story of Candide, we are bombarded with horrendous events that happened to an individual to disprove Pangloss’s teachings. Candide’s adventures encountered such atrocities as murder, rape, slavery, and prostitution. The bad events that occur in Candide, help show that the world is not perfect, and that not everything happens for the greater good in the end. Candide’s adventures, great in number, show us how bad others lives turned out as well as their friends and families lives were hurt as well, such as the old woman. In the end, Candide finally realizes that optimism is not a flawless philosophy, and that the idea of working hard and enjoying life is better than waiting around for the good you think will happen. Candide’s adventures helped to contradict optimism and ultimately changed Candide’s beliefs from optimism to a realization of reality. Candide begins to live a simple life, working hard to avoid boredom, vice, and pov erty.

Strategic Initiative

If the strategic plan is properly prepared and understood, then the company will continue to grow and thrive. Wall-Mart is a multimillion dollar empire that provides goods and services to communities all over the world. They are able to do this is because they are constantly looking for new ways to keep their business growing while keeping their customers satisfied and coming back for more. In this paper, Team C has developed a strategic planning initiative that will help Wall-Mart appeal In the local community.The strategic plan will help readers understand how financial planning plays a large part in the success and failure of a business by looking at costs and sales in the community, and finally ascribing the risks that are associated with the strategic planning initiative and financial effects they may have on the company. Strategic Planning Initiative Financial planning is about finding out how the business is going to financially in the future. This means that reports from acco unting and other departments have to be correct or else the forecasting will not be accurate.When a business is working on their financial planning they need to prepare a cash budget. Financial planning helps a business to know how the profits will look in the future which In turn will help them plan on other things. This is where the strategic planning comes Into play. The company can plan how much merchandise to receive for parts of ten year. I nee can also Tugged Tort Dulling expansions, malfeasance, Ana toner necessary things. By knowing how much they can spend on certain projects with the amount they have received from the financial forecasting they can budget properly.They can take the time to plan smart and know what they can do for the company and what they cannot do. Wall-Mart is planning on getting their supplies and merchandise from responsible sources. They want to make sure that the products that they sell to their nonusers are safe to eat and that with our busy lives t hey want the products to stand the wear and tear. With the help of the safer and stronger merchandise, Wall- Mart is planning on increasing sales and make sure that they are making the importance of their values known.With this said from the annual report, Wall-Mart is also working with Michelle Obama to make their food products healthier and their produce cheaper. (womb. Anytime. Com) Mrs.. Obama is helping to reduce obesity in children and trying to make foods healthier. Wall-Mart has been meeting with the first dad and are going to take their brand, Great Value, and make it to where it has less fats, sugars, and unhealthy salts. They are going to come out with healthier soups, salad dressings, rice and snacks.Wall-Mart is also trying to get Kraft to follow their examples and produces healthier products. Initiative Affects on Costs The new initiative will not have a major effect on cost for Wall-Mart. Wall-Mart will continue to use its current manufacturers to be able to provide t heir consumers with the most economical prices. Some things that have caused a change in cost for Wall- Mart would be the improvement of labor productivity and also organizational changes that have been made.There may be several changes that may occur in the upcoming year, but with their past experience Wall-Mart is fully prepared to embrace the changes in the most efficient way possible. They will continue to provide better health benefits to their employees and will be more strategic in their advertising. Also, with the Wall-Mart website they are cutting cost by not having so many items to ship and stock in their stores. It also provides their consumers to have easy access to he products which will expand their clientele.Initiative Affects on Sales Wall-Mart's two initiatives that our team focused on are not only driven by expectations of rising sales, but are thoughtful of improving society in small ways. The initiatives focus on improving the health of consumers, helping them to make smarter choices when doing the food shopping. Very aware of the effects of the economy, Wall-Mart is also finding ways to make these healthy choices affordable and realistic. Quality and values are what they are aiming to reveal, being responsible ND thoughtful so that buying Wall-Mart products is an easy and smart solution for better everyday living.With such a strong platform, these initiatives should easily lure American's into one of their 3,804 stores, targeting the common need to live smart and healthy lives on a budget, in order to accommodate the current state of ten economy. â€Å"We are expanding our assortment, re-allocating selling space Ana enhancing productivity initiatives to reduce costs† (Wall-Mart, 2011). By working with suppliers Wall-Mart is aiming to expand assortment in all categories and make the assortment more relevant. We continue to implement productivity initiatives throughout the stores, supply chain and logistics to improve returns. As we s ee top- line sales increase through our focus on IDLE (everyday low prices) and from operational and merchandising improvements, we can further enhance our ability to drive expense leverage† (Wall-Mart, 2011). With cost reduction and commitment to the focus at the core of the Wall-Mart organization, everyday low prices, sales will continue to rise, and the trust and loyalty consumers already show will grow even trotter.Risks Associated with Initiative and Financial Effects As with any business it is important to assess the risks and the financial affects of a business initiative. For Wall-Mart, three initiatives have been identified. The first is purchasing supplies from a responsible supplier. The second is to produce healthier food products in conjunction with the support of Michelle Obama. The third is to promote cheaper produce which will encourage families to eat healthier. The identified associated risks are the possibility of limited resources from so-called expansible suppliers causing Wall-Mart to limit goods that they sell.In addition, there is the possibility of higher cost associated with responsible supplier which will then be trickled down to consumers. Lastly, there is definite risk of botulism or reduced sales associated with purchasing lower quality produce in order to meet their initiative of cheaper produce. With any risk there are also potential financial affects which are the effect of the associated risks. For Wall-Mart they may find that they have to pay more for goods that are form responsible manufacturers and appliers which in turn which trickle down to the consumers causing them to pay more for goods.In turn, causes Wall-Mart to lose customers due to higher pricing. On the other hand if Wall-Mart is able to budget for the absorption of the additional costs and see no price rise to their consumers then they may actually see a financial benefit. Wall-Mart envisions cheaper produce as a potential benefit to its customers and it ca n be but the key to this success will be purchasing cheaper produce that is still quality produce and offering it at an everyday low price to consumers.On the other hand if Wall-Mart offers cheap produce that is not quality produce they may see a reduction in revenue and a loss of customers in this area. Conclusion Wall-mart has over 3,804 stores worldwide, and is the largest leader in retail sales. Wall-mart is able to do this by expanding their business into other countries and providing great quality items to their customers at low prices. The best way for Wall-mart to grow even bigger than they already are is to create a strategic initiative plan that is firm and reliable.